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Te and participated in preparation of Methods section and discussion of the results, ZL performed the analysis of microarray data, JR participated in discussion of the data and the manuscript, HP conceived of the study, and participated in its design andPage 14 of(page number not for citation purposes)Molecular Cancer 2009, 8:http://www.molecular-cancer.com/content/8/1/coordination and was involve
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Ate CaMKII activation leading to MMP-9 expression. As shown in Figure 4C, LTA stimulated a time-dependent phosphorylation of CaMKII. A maximal response was obtained within 3 min and then declined within 60 min. LTA-stimulated CaMKII phosphorylation was significantly attenuated by pretreatment with CaMI (5 M) or KN-62 (10 M) during the period of observation, respectively (Figure 4D). To ascertain t
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Re national guidelines for severe sepsis were published. Methods A prospective observational study of patients with severe sepsis and septic shock admitted to 21 ICUs in Finland from 1 November 2004 to 28 February 2005 (Finnsepsis). Only patients with community-acquired sepsis, who fulfilled the criteria of septic shock and were admitted directly from the ED to the ICU, were included. The followin
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